Potent and selective inhibitor of TGF-β1 superfamily activin receptor-like kinase (ALK), specifically at ALK5 (IC50: 94 nM) and its relatives ALK4 (IC50: 140 nM) and ALK7; SB431542 inhibits endogenous activin and TGF-β signaling, but has no effect on BMP signaling; a useful tool for studing the role of TGF-β, activin and many cellular processes.

*Promotion: SB 431542 is also part of Inhibitor Set(s):

KEYWORDS: SB 431542 | supplier | ALK5 inhibitor | SB431542 | CAS [301836-41-9] | TGF-β1 | TGF-beta | RSTK | activin receptor-like kinase | BMP signaling | Transforming Growth Factor | osteosarcoma