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DMH-1
Axon 4387
CAS:
1206711-16-1
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C24H20N4O
- MW: 380.44
Description
DMH-1 is a potent and highly selective BMP inhibitor with an IC50 value of 107.9 nM for ALK2 (BMPR-I). DMH1 exclusively targets the BMP but not the VEGF pathway, dorsalized the embryonic axis without disrupting the angiogenic process, demonstrating that BMP signaling was not involved in the angiogenic process. DMH-1 promotes neurogenesis of hiPSCs.
More Information
| Parent CAS No. | 1206711-16-1 |
|---|---|
| Chemical Name | 6-(4-Isopropoxyphenyl)-3-(4-quinolyl)-1,4,7a-triazaindene |
| SMILES | C1=CC(C2=CN3N=CC(C4=C5C=CC=CC5=NC=C4)=C3N=C2)=CC=C1OC(C)C |
| MFCD | MFCD18384963 |
| InChi | InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3 |
| InChiKey | JMIFGARJSWXZSH-UHFFFAOYSA-N |
| CID | 50997747 |
| Short Description | BMP inhibitor |
References
- J Hao et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5(2):245-53.
- MD Neely et al. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem Neurosci. 2012 Jun 20;3(6):482-91.
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