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Fexofenadine hydrochloride
- Parent CAS: 83799-24-0
- Soluble in DMSO
- MF: C32H39NO4.HCl
- MW: 538.12
Description
Fexofenadine hydrochloride is a peripherally selective, second-generation histamine H1 receptor antagonist with minimal central sedative activity.
Fexofenadine blocks histamine-driven vascular permeability, sensory-nerve activation and allergic symptoms without substantial blood–brain barrier penetration. It is a clinically relevant standard for H1 receptor, allergy and peripheral antihistamine studies.
Key Features
- Selective peripheral H1 receptor antagonist
- Low central nervous system penetration
- Blocks histamine-mediated allergic responses
- Clinically established non-sedating antihistamine pharmacology
Applications
- H1 receptor binding and functional assays
- Mast-cell and histamine-response studies
- Allergic rhinitis and urticaria models
- Peripheral versus central antihistamine profiling
More Information
| Parent CAS No. | 83799-24-0 |
|---|---|
| Chemical Name | 2-(4-{1-Hydroxy-4-[4-(hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-phenyl)-2-methyl-propionic acid |
| SMILES | C1CN(CCCC(O)C2C=CC(C(C)(C)C(O)=O)=CC=2)CCC1C(O)(C1C=CC=CC=1)C1C=CC=CC=1.Cl |
| MFCD | MFCD00865710 |
| InChi | InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H |
| InChiKey | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| CID | 63002 |
| Short Description | H1 antagonist |
References
- PV Dicpinigaitis and YE Gayle. Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function. Br. J. Clin. Pharmacol. 2003, 56 (5), 501–504.
- GA Vena et al. Fexofenadine in chronic idiopathic urticaria: a clinical and immunohistochemical evaluation. Int. J. Immunopathol. Pharmacol. 2002, 15 (3), 217–224.
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