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AS 1517499
- Soluble in DMSO
- MF: C20H20ClN5O2
- MW: 397.86
Description
Potent and selective STAT6 inhibitor (IC50: 21 nM)
More Information
| Parent CAS No. | 919486-40-1 |
|---|---|
| Chemical Name | 4-(benzylamino)-2-(3-chloro-4-hydroxyphenethylamino)pyrimidine-5-carboxamide |
| SMILES | C1(NCCC2=CC=C(O)C(Cl)=C2)=NC=C(C(N)=O)C(NCC2=CC=CC=C2)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26) |
| InChiKey | OZRMEKAUZBKTTC-UHFFFAOYSA-N |
| CID | 10340781 |
| Short Description | STAT6 inhibitor |
References
- S Nagashima et al. Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg. Med. Chem. 2007, 15(2), 1044-1055.
- Y Chiba et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am. J. Respir. Cell Mol. Biol. 2009, 41(5), 516-524.
- K Goto et al. The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells. Pharmacol. Res. 2010, 61(5), 466–472.
- B Jiao et al. Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Front Immunol. 2021 Aug 26;12:735014.
- List of publications using AS 1517499 (Axon 1992) purchased from Axon Medchem
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