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Tenovin 6

 - Tnv 6
Axon 2249
CAS:  1011557-82-6
Purity:  99%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C25H34N4O2S
  • MW:  454.63

Description

Small molecule, water soluble p53 activator and SIRT inhibitor (IC50 values of 21 μM, 10 μM, and 67 μM for purified human SIRT1, 2, and 3, respectively, in a peptide deacetylase assay). Tenovin 6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulation of autophagy, without increasing p53-pathway activity. It induces p53-dependent apoptosis in many malignant cells.

More Information

Parent CAS No. 1011557-82-6
Chemical Name 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide
SMILES C(NC(NC1=CC=C(NC(=O)CCCCN(C)C)C=C1)=S)(=O)C1=CC=C(C(C)(C)C)C=C1
MFCD MFCD11976906
InChi InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)
InChiKey BVJSXSQRIUSRCO-UHFFFAOYSA-N
CID 24772043
Short Description SIRT inhibitor

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