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Selisistat
- EX 527
- Soluble in DMSO
- MF: C13H13ClN2O
- MW: 248.71
Description
Selisistat (EX527) is a potent and selective sirtuin 1 (SIRT1) inhibitor. It inhibits SIRT1-dependent NAD+-dependent deacetylase activity and is widely used to study protein acetylation-dependent regulation.
SIRT1 regulates transcriptional programs linked to metabolism, stress responses, aging biology, DNA repair and neurodegeneration. Selisistat is relevant for investigating SIRT1 pharmacology, epigenetic regulation and Huntington disease-related cellular models.
Key Features
- Selective SIRT1 deacetylase inhibitor
- Modulates NAD+-dependent protein deacetylation
- Useful tool for acetylation-dependent cell regulation studies
- Relevant to neurodegeneration and stress-response research
Applications
- SIRT1 enzyme assays
- Epigenetic and transcriptional regulation studies
- Neurodegeneration model research
- Metabolic and stress-response pathway analysis
More Information
| Parent CAS No. | 49843-98-3 |
|---|---|
| Chemical Name | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| SMILES | N1C2=C(C=C(Cl)C=C2)C2=C1C(C(N)=O)CCC2 |
| MFCD | MFCD03009471 |
| InChi | InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17) |
| InChiKey | FUZYTVDVLBBXDL-UHFFFAOYSA-N |
| CID | 5113032 |
| Short Description | SIRT1 inhibitor |
References
- AD Napper et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J. Med. Chem. 2005, 48, 8045-8054.
- JC Milne et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007, 450(7170), 712-716.
- JM Solomon et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006, 26(1), 28-38.
- Y Zhang et al. Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene. 2009, 28(3), 445-60.
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