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SIRT7 inhibitor 97491
- Soluble in DMSO
- MF: C15H12ClN3O
- MW: 285.73
Description
SIRT7 inhibitor 97491 is a potent SIRT7 inhibitor that suppresses SIRT7 enzymatic activity in a dose-dependent manner with an IC50 value of 0.325 μM. The compound increases p53 acetylation and expression through inhibition of SIRT7-mediated deacetylation pathways.
SIRT7 is a member of the sirtuin family of NAD+-dependent deacetylases and plays important roles in chromatin regulation, ribosome biogenesis, cellular metabolism, stress responses, aging, and cancer progression. Pharmacological inhibition of SIRT7 by SIRT7 inhibitor 97491 promotes activation of p53 signaling, upregulates caspase-dependent apoptotic pathways, and suppresses tumor growth in vivo. The compound therefore serves as a valuable chemical probe for studying sirtuin biology, epigenetic regulation, apoptosis, and cancer-associated SIRT7 signaling.
Key Features
- Potent SIRT7 inhibitor
- IC50: 0.325 μM
- Increases p53 expression and acetylation
- Activates caspase-dependent apoptotic pathways
- Suppresses tumor growth in vivo
Applications
- SIRT7 biology and target validation studies
- Sirtuin signaling and epigenetics research
- p53 pathway investigations
- Apoptosis and cancer biology studies
- Cellular stress response and aging research
More Information
| Parent CAS No. | 1807758-81-1 |
|---|---|
| Chemical Name | N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine |
| SMILES | C1C=CC(NC2=NC=C(C3C=CC(Cl)=CC=3)O2)=CC=1N |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12ClN3O/c16-11-6-4-10(5-7-11)14-9-18-15(20-14)19-13-3-1-2-12(17)8-13/h1-9H,17H2,(H,18,19) |
| InChiKey | RMRVZWMKRCLSFX-UHFFFAOYSA-N |
| CID | 146018038 |
| Short Description | SIRT7 inhibitor |
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