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Salermide
- Soluble in DMSO
- MF: C26H22N2O2
- MW: 394.47
Description
Salermide is a reverse amide with a potent in vitro inhibitory effect on Sirt1 and Sirt2. Salermide was well tolerated by mice at concentrations up to 100 μM and prompted tumour-specific cell death in a wide range of human cancer cell lines. It induces massive apoptosis in cancer but not in non-transformed cultured cells. The apoptotic effect of Salermide is in part because of the reactivation of proapoptotic genes that are epigenetically repressed by Sirt1 exclusively in cancer cells.
More Information
| Parent CAS No. | 1105698-15-4 |
|---|---|
| Chemical Name | N-(3-((2-Hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide |
| SMILES | C1C=C2C(/C=N/C3C=CC=C(NC(=O)C(C)C4C=CC=CC=4)C=3)=C(O)C=CC2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+ |
| InChiKey | HQSSEGBEYORUBY-WPWMEQJKSA-N |
| CID | 135659046 |
| Short Description | SIRT inhibitor |
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