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SirReal 2
- Soluble in DMSO
- MF: C22H20N4OS2
- MW: 420.55
Description
SIRT2 inhibitor (IC50 value 0.14 µM) with in vivo activity, showing >1000 fold selectivity over other Class-I sirtuins SIRT1 and SIRT3. Application of SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1.
More Information
| Parent CAS No. | 709002-46-0 |
|---|---|
| Chemical Name | 2-(4,6-dimethylpyrimidin-2-ylthio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide |
| SMILES | C(NC1=NC=C(CC2=C3C(C=CC=C3)=CC=C2)S1)(=O)CSC1=NC(C)=CC(C)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27) |
| InChiKey | MENNDDDTIIZDDN-UHFFFAOYSA-N |
| CID | 1096292 |
| Short Description | SIRT2 inhibitor |
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