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Cambinol
- NSC 112546
- Soluble in DMSO
- MF: C21H16N2O2S
- MW: 360.43
Description
Cambinol is a cell-permeable inhibitor of the NAD-dependent deacetylases SIRT1 and SIRT2, with reported IC50 values of 56 µM and 59 µM, respectively. It increases acetylation of stress-response and chromatin-associated proteins and can promote cell-cycle arrest under genotoxic stress.
Cambinol also inhibits neutral sphingomyelinase 2 (nSMase2/SMPD3) by an uncompetitive mechanism, with a reported Ki value of 7 µM, making nSMase2 inhibition a prominent activity at lower concentrations than sirtuin inhibition. It is useful for studying sirtuin biology, ceramide production, extracellular-vesicle pathways and stress responses.
Key Features
- Dual SIRT1/SIRT2 inhibitor
- IC50: 56 µM for SIRT1 and 59 µM for SIRT2
- Uncompetitive nSMase2 inhibitor
- Ki: 7 µM for nSMase2
- Modulates protein acetylation and sphingolipid signaling
Applications
- SIRT1 and SIRT2 research
- nSMase2 and ceramide biology
- Protein-acetylation studies
- Extracellular-vesicle research
- Genotoxic-stress and cell-cycle assays
More Information
| Parent CAS No. | 14513-15-6 |
|---|---|
| Chemical Name | 5-((2-Hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
| SMILES | C1C=C2C(CC3=C(C4C=CC=CC=4)NC(=S)NC3=O)=C(O)C=CC2=CC=1 |
| MFCD | MFCD09057543 |
| InChi | InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) |
| InChiKey | RVNSQVIUFZVNAU-UHFFFAOYSA-N |
| CID | 3246390 |
| Short Description | SIRT inhibitor |
References
- B Heltweg et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77.
- M Figuera-Losada et al. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015 May 26;10(5):e0124481.
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