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Sirtinol
- Soluble in DMSO
- MF: C26H22N2O2
- MW: 394.47
Description
Sirtinol is a specific sirtuin (SIRT) inhibitor.
More Information
| Parent CAS No. | 410536-97-9 |
|---|---|
| Chemical Name | 2-((2-Hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide |
| SMILES | C1C=CC2C(/C=N/C3C=CC=CC=3C(=O)NC(C)C3C=CC=CC=3)=C(O)C=CC=2C=1 |
| MFCD | MFCD00810186 |
| InChi | InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+ |
| InChiKey | UXJFDYIHRJGPFS-WPWMEQJKSA-N |
| CID | 2827646 |
| Short Description | SIRT inhibitor |
References
- J Wang et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-9.
- Y Fong et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051.
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