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AGK2
- Soluble in DMSO
- MF: C23H13Cl2N3O2
- MW: 434.27
Description
AGK2 is a potent and selective inhibitor of sirtuin 2 (SIRT2) with an IC50 value of 3.5 nM. Inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease.
More Information
| Parent CAS No. | 304896-28-4 |
|---|---|
| Chemical Name | N-5-Quinolyl-2-cyano-3-(5-(2,5-dichlorophenyl)-2-furyl)acrylamide |
| SMILES | C1(Cl)=CC(C2=CC=C(/C=C(/C(=O)NC3C4C=CC=NC=4C=CC=3)C#N)O2)=C(Cl)C=C1 |
| MFCD | MFCD01909444 |
| InChi | InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+ |
| InChiKey | SVENPFFEMUOOGK-SDNWHVSQSA-N |
| CID | 2130404 |
| Short Description | SIRT2 inhibitor |
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