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GS 39783
- Moderately soluble in DMSO
- MF: C15H23N5O2S
- MW: 337.44
Description
More Information
| Parent CAS No. | 39069-52-8 |
|---|---|
| Chemical Name | N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine |
| SMILES | N1C(NC2CCCC2)=C([N+]([O-])=O)C(NC2CCCC2)=NC=1SC |
| MFCD | MFCD06201849 |
| InChi | InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) |
| InChiKey | GSGVDKOCBKBMGG-UHFFFAOYSA-N |
| CID | 6604928 |
| Short Description | GABA-B PAM |
References
- S Urwyler et al. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function. J. Pharmacol. Exp. Ther. 2003, 307(1), 322-330.
- C Mombereau et al. Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior. Neuropsychopharmacol. 2004, 29(6), 1050-1062.
- P Maccioni et al. Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats. Psychopharmacology (Berlin). 2007, 193(2), 171-178.
- NE Paterson et al. Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats. J. Pharmacol. Exp. Ther. 2008, 326(1), 306-314.
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