Bulk Inquiry
Alofanib
- RPT835 - ES000835
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C19H15N3O6S
- MW: 413.4
Description
Alofanib is an allosteric inhibitor of FGFR2 and significantly inhibited bFGF-induced proliferation of HUVEC cells (IC50 value of 11 nM) and suppressed proliferation of SVEC-4-10 cells (IC50 value of 58 nM). Moreover, Alofanib suppressed the migration activity of endothelial cells, and their ability to form vessel-like structures in vitro. Also, Alofanib significantly decreased the number of microvessels in Matrigel implant and in ovarian cancer (SKOV-3) xenograft in vivo.
More Information
| Parent CAS No. | 1612888-66-0 |
|---|---|
| Chemical Name | 3-(N-(4-Methyl-2-nitro-5-(pyridin-3-yl)phenyl)sulfamoyl)benzoic acid |
| SMILES | C1C([N+]([O-])=O)=C(NS(C2C=C(C(O)=O)C=CC=2)(=O)=O)C=C(C2C=NC=CC=2)C=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24) |
| InChiKey | QUQGQIASFYWKAB-UHFFFAOYSA-N |
| CID | 86280646 |
| Short Description | FGFR2 inhibitor |
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