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OTS964 hydrochloride
- Parent CAS: 1338542-14-5
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C23H24N2O2S.HCl
- MW: 428.97
Description
OTS964 hydrochloride is a TOPK small molecular inhibitor, binding to the enzyme potently and selectively with IC50 at lower nM. The inhibition causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. The free base OTS-964 (Axon 3876) is also available.
More Information
| Parent CAS No. | 1338542-14-5 |
|---|---|
| Chemical Name | (R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one hydrochloride |
| SMILES | C1(C2C=CC([C@@H](C)CN(C)C)=CC=2)C(O)=CC(C)=C2NC(=O)C3SC=CC=3C=12.Cl |&1:5,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | TOPK inhibitor |
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