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Tofacitinib citrate
- CP 690550-10
- Parent CAS: 477600-75-2
- Soluble in DMSO
- MF: C16H20N6O.C6H8O7
- MW: 504.49
Description
Potent Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis; the citrate salt form of CP 690550 - Tofacitinib (Axon 1338)
More Information
| Parent CAS No. | 477600-75-2 |
|---|---|
| Chemical Name | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate |
| extra_info | . |
| MFCD | MFCD11616529 |
| Short Description | JAK3 inhibitor |
References
- AC Papageorgiou et al. Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 2004, 25(11), 558-562.
- E Kudlacz et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am. J. Transplant. 2004, 4, 51-57.
- E Kudlacz et al. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582, 154-161.
- PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Sci. 2003, 302(5646), 875-878.
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