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CP 690550
- Tasocitinib - Tofacitinib
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C16H20N6O
- MW: 312.37
Description
Janus Kinase 3 (JAK3) inhibitor; an immunosuppressive agent exhibiting potent effects in preclinical transplantation and arthritis models; clinically safe and effective in preventing transplant rejection and improving symptoms of rheumatoid arthritis and psoriasis.
This product is also available as its citrate salt form, Tofacitinib citrate (Axon 2072).
More Information
| Parent CAS No. | 477600-75-2 |
|---|---|
| Chemical Name | 3-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile |
| extra_info | . |
| MFCD | MFCD11035919 |
| Short Description | JAK3 inhibitor |
References
- LA Sorbera et al. CP-690550, Drugs Fut. 2007, 32(8), 674.
- AC Papageorgiou and LEK Wikman, Is JAK3 a new drug target for immunomodulation-based therapies? Trends Pharmacol. Sci. 2004, 25(11), 558-562.
- E Kudlacz et al. The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Am. J. Transplant. 2004, 4(1), 51-7.
- E Kudlacz et al. The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia. Eur. J. Pharmacol. 2008, 582(1-3), 154-61.
- PS Changelian et al. Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Sci. 2003, 302(5646), 875-878.
- List of publications using CP 690550 (Axon 1338) purchased from Axon Medchem
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