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XMD 8-92
- Soluble in DMSO
- MF: C26H30N6O3
- MW: 474.55
Description
Potent and selective inhibitor of big MAP kinase 1 (BMK1/ERK5).
Note: XMD 8-92 is also available as water soluble TFA-salt (Axon 1621)
More Information
| Parent CAS No. | 1234480-50-2 |
|---|---|
| Chemical Name | 2-(2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one |
| extra_info | Sold under agreement with the Dana-Faber Cancer Institute |
| SMILES | C1(OCC)C=C(N2CCC(O)CC2)C=CC=1NC1N=C2N(C)C3C=CC=CC=3C(=O)N(C)C2=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29) |
| InChiKey | QAPAJIZPZGWAND-UHFFFAOYSA-N |
| CID | 46843772 |
| Short Description | BMK1/Erk5 inhibitor |
References
- Q. Yang et al. Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein. Cancer Cell, 2010, 18(3), 258-267.
- Q Yang and JD Lee. Targeting the BMK1 MAP Kinase Pathway in Cancer Therapy. Clin. Cancer Res. 2011, 17, 3527-3532.
- BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48.
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