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Irestatin 9389
- Soluble in DMSO
- MF: C16H13F3N4OS2
- MW: 398.43
Description
Irestatin 9389 is a potent IRE1 endoribonuclease inhibitor with an IC50 value of 6.3 nM and activity against the unfolded protein response.
IRE1α is a central ER stress sensor that mediates XBP1 mRNA splicing and adaptive UPR signaling. Irestatin 9389 is useful for interrogating ER stress biology, secretory pathway stress responses and IRE1-dependent survival mechanisms.
Key Features
- Potent inhibitor of IRE1 RNase activity
- IC50: 6.3 nM
- Modulates unfolded protein response signaling
- Useful for studying XBP1-dependent ER stress pathways
Applications
- Unfolded protein response research
- IRE1α/XBP1 pathway studies
- ER stress and proteostasis models
- Cancer and secretory cell stress assays
More Information
| Parent CAS No. | 626221-47-4 |
|---|---|
| Chemical Name | 2-(3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-ylthio)-N-(4-methylthiazol-2-yl)acetamide |
| SMILES | C12CCCC=1N=C(SCC(=O)NC1=NC(C)=CS1)C(C#N)=C2C(F)(F)F |
| MFCD | MFCD03697924 |
| InChi | InChI=1S/C16H13F3N4OS2/c1-8-6-26-15(21-8)23-12(24)7-25-14-10(5-20)13(16(17,18)19)9-3-2-4-11(9)22-14/h6H,2-4,7H2,1H3,(H,21,23,24) |
| InChiKey | OQPKODFAFXMGNC-UHFFFAOYSA-N |
| CID | 1005519 |
| Short Description | IRE1 inhibitor |
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