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L-742001 hydrochloride
Axon 4228
- Parent CAS: 177592-42-6
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C23H24ClNO4.HCl
- MW: 450.35
Description
L-742001 hydrochloride is an inhibitor of influenza virus PA endonuclease. Moreover, L-742001 is a first-in-class highly selective inhibitor of cap-dependent endonuclease of influenza viruses (IC50 value of 0.43 µM for in vitro influenza virus transcription).
More Information
| Parent CAS No. | 177592-42-6 |
|---|---|
| Chemical Name | (Z)-4-(1-Benzyl-4-(4-chlorobenzyl)piperidin-4-yl)-2-hydroxy-4-oxobut-2-enoic acid hydrochloride |
| SMILES | N1(CC2C=CC=CC=2)CCC(CC2C=CC(Cl)=CC=2)(C(/C=C(O)/C(=O)O)=O)CC1.Cl |
| MFCD | MFCD22587878 |
| InChi | InChI=1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-; |
| InChiKey | LMLNSXCRZNNZBT-VSOKSMTPSA-N |
| CID | 71779114 |
| Short Description | PA endonuclease inhibitor |
References
- JC Hastings et al. Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7.
- A Stevaert et al. An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease. Mol Pharmacol. 2015 Feb;87(2):323-37.
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