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FEN1 inhibitor 1
- LNT1
Axon 3027
CAS:
824983-91-7
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H12N2O5S
- MW: 332.33
Description
FEN1 inhibitor 1 is a potent flap endonuclease-1 (FEN1) inhibitor with an IC50 value of 0.011 μM. FEN1 inhibitor 1 was shown to sensitize bladder carcinoma cells to DNA damage that is normally repaired by the BER pathway.
More Information
| Parent CAS No. | 824983-91-7 |
|---|---|
| Chemical Name | 1-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione |
| SMILES | C1(=O)N(O)C(=O)N(CC2COC3C=CC=CC=3O2)C2C=CSC1=2 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2 |
| InChiKey | MXQGCMQXTPTJJT-UHFFFAOYSA-N |
| CID | 11652865 |
| Short Description | FEN1 inhibitor |
References
- TA Ward et al. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.
- JC Exell et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016 Oct;12(10):815-21.
- LN Tumey et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.
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