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4μ8C
Axon 1902
CAS:
14003-96-4
Purity:
99%
- Soluble in DMSO
- MF: C11H8O4
- MW: 204.18
Description
4μ8C (4mu8C) is a potent and selective IRE1α RNase inhibitor with a reported IC50 value of 60 nM.
IRE1α is an endoplasmic reticulum stress sensor that mediates XBP1 mRNA splicing and regulated IRE1-dependent decay of RNA substrates. 4μ8C blocks substrate access to the IRE1α RNase active site, enabling selective suppression of IRE1-dependent unfolded protein response outputs.
Key Features
- Selective IRE1α RNase inhibitor
- IC50: 60 nM
- Blocks XBP1 mRNA splicing and IRE1-mediated RNA degradation
- Useful for unfolded protein response and ER stress studies
Applications
- IRE1α pathway pharmacology
- XBP1 splicing assays
- ER stress and unfolded protein response research
- RIDD and RNA-processing studies
More Information
| Parent CAS No. | 14003-96-4 |
|---|---|
| Chemical Name | 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde |
| SMILES | C1(O)C(C=O)=C2OC(=O)C=C(C)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3 |
| InChiKey | RTHHSXOVIJWFQP-UHFFFAOYSA-N |
| CID | 12934390 |
| Short Description | IRE1 inhibitor |
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