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Azoramide
- Soluble in DMSO
- MF: C15H17ClN2OS
- MW: 308.83
Description
Azoramide is a small-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 µM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models.
UPR pharmacology is highly relevant to both obesity and oncology research; Azoramide supports mechanistic studies of UPR, PERK, IRE1 pathways across biochemical, cellular and disease-model assays.
Key Features
- UPR modulator
- Upregulates critical protein-folding chaperones like BiP/GRP78
- Enhances the physical folding capacity of the endoplasmic reticulum
- Blocks pro-apoptotic PERK-CHOP signaling to prevent cell death.
Applications
- UPR pharmacology and target-validation studies
- UPR pathway and signaling assays
- Disease-model research related to obesity and oncology
- Kinase signaling, phosphorylation and pathway-inhibition assays
More Information
| Parent CAS No. | 932986-18-0 |
|---|---|
| Chemical Name | N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyramide |
| SMILES | C(NCCC1=CSC(C2=CC=C(Cl)C=C2)=N1)(=O)CCC |
| MFCD | MFCD08009374 |
| InChi | InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19) |
| InChiKey | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
| CID | 7518316 |
| Short Description | UPR modulator |
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