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ISRIB
- trans-ISRIB
- Soluble in DMSO
- MF: C22H24Cl2N2O4
- MW: 451.34
Description
First reported, potent and selective inhibitor of the ‘integrated stress response’ (ISR) and a potent inhibitor of PERK signaling. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50 value of 5 nM for inhibition of ATF4-luciferase reporter). Trans-ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, and proved to be 100-fold more potent than cis-ISRIB, indicating that the compound’s interaction with its cellular target is stereospecific.
More Information
| Parent CAS No. | 1597403-47-8 |
|---|---|
| Chemical Name | N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
| MFCD | N.A. |
| Short Description | ISR inhibitor |
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