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AA147
Axon 3416
CAS:
393121-74-9
Purity:
99%
- Soluble in DMSO
- MF: C16H17NO2
- MW: 255.31
Description
AA147 is an endoplasmic reticulum (ER) proteostasis regulator. The ER reprogramming afforded by AA147 requires activation of endogenous ATF6 and occurs independent of global ER stress. Also, AA147 is broad-spectrum inhibitor of dengue and Zika virus infections.
More Information
| Parent CAS No. | 393121-74-9 |
|---|---|
| Chemical Name | N-(2-Hydroxy-5-methylphenyl)-3-phenylpropanamide |
| SMILES | C1C=C(CCC(=O)NC2C=C(C)C=CC=2O)C=CC=1 |
| MFCD | MFCD01881999 |
| InChi | InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19) |
| InChiKey | AWHLTHOHBAGPMY-UHFFFAOYSA-N |
| CID | 882909 |
| Short Description | ER proteostasis regulator |
References
- L Plate et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife. 2016 Jul 20;5:e15550.
- KM Almasy et al. Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2012209118.
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