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ErSO-DFP
Axon 4332
CAS:
2768139-76-8
- Optical Purity: >98.5% e.e.
- Soluble in DMSO
- MF: C20H17F5N2O2
- MW: 412.35
Description
A much-improved version of ErSO (Axon 3594), ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO. ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model.
More Information
| Parent CAS No. | 2768139-76-8 |
|---|---|
| Chemical Name | (R)-3-(4,4-Difluoropiperidin-1-yl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C2[C@](N3CCC(F)(F)CC3)(C3C=CC(O)=CC=3)C(=O)NC2=C(C(F)(F)F)C=1 |&1:3,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | a-UPR activator |
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