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BIRB 796
- BIRB 0796 - Doramapimod
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C31H37N5O3
- MW: 527.66
Description
Small molecule inhibitor of p38 mitogen-activated protein (MAP) kinase (MAPK); more potent than SB 203580 (Axon 1363) on p38α and p38β MAPKs; potential agent for the treatment of inflammatory diseases
*Promotion: BIRB 796 is also part of Inhibitor Set(s):
| Naive Stem Cell NHSM inhibitor Set (Axon 5010) |
More Information
| Parent CAS No. | 285983-48-4 |
|---|---|
| Chemical Name | 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea |
| SMILES | N1(N=C(C(C)(C)C)C=C1NC(=O)NC1C=CC(OCCN2CCOCC2)=C2C=CC=CC=12)C1C=CC(C)=CC=1 |
| MFCD | MFCD09752957 |
| InChi | InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) |
| InChiKey | MVCOAUNKQVWQHZ-UHFFFAOYSA-N |
| CID | 156422 |
| Short Description | p38 MAPK inhibitor |
References
- C Pargellis et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat. Struct. Biol. 2002, 9, 268-272.
- Y Kuma et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J. Boil. Chem. 2005, 280, 19472-19479.
- J Bain et al. The selectivity of protein kinase inhibitors: a further update.Biochem J. 2007, 408, 297–315.
- List of publications using BIRB 796 (Axon 1358) purchased from Axon Medchem
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