List of publications using BIRB 796 (Axon 1358) purchased from Axon Medchem

(Total 71 publication citations listed; updated in AUGUST-2017)

2017
Nishimura, T., Unezaki, N., Kanegi, R., Wijesekera, H. D. P., Hatoya, S., Sugiura, K., ... & Inaba, T. (2017). Generation of Canine Induced Extraembryonic Endoderm-Like Cell Line that Forms Both Extraembryonic and Embryonic Endoderm Derivatives. Stem Cells and Development, (ja).
http://online.liebertpub.com/doi/abs/10.1089/scd.2017.0026 

Hagmann, B. R., Odermatt, A., Kaufmann, T., Dahinden, C. A., & Fux, M. (2017). Balance between IL‐3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils. Clinical & Experimental Allergy, 47(1), 71-84.
http://onlinelibrary.wiley.com/doi/10.1111/cea.12850/full 

Hirata, S., Murata, T., Suzuki, D., Nakamura, S., Jono‐Ohnishi, R., Hirose, H., ... & Eto, K. (2017). Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell‐Derived Platelets. Stem cells translational medicine, 6(3), 720-730. 

Jokela, T., Kärnä, R., Rauhala, L., Bart, G., Pasonen-Seppänen, S., Oikari, S., ... & Tammi, R. H. (2017). Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis. Journal of Biological Chemistry, 292(12), 4861-4872.
http://www.jbc.org/content/292/12/4861.full 

Dunoyer-Geindre, S., Rivier-Cordey, A. S., Tsopra, O., Lecompte, T., & Kruithof, E. K. (2017). Effect of ATRA and ATO on the expression of tissue factor in NB4 acute promyelocytic leukemia cells and regulatory function of the inflammatory cytokines TNF and IL-1β. Annals of Hematology, 96(6), 905-917.
https://link.springer.com/article/10.1007/s00277-017-2970-5

Luo, M., Yeruva, S., Liu, Y., Chodisetti, G., Riederer, B., Menon, M. B., ... & Seidler, U. E. (2017). IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. Frontiers in physiology, 8. 61.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293818/

Newell, L. F., Holtan, S. G., Yates, J. E., Pereira, L., Tyner, J. W., Burd, I., & Bagby, G. C. (2017). PlGF enhances TLR‐dependent inflammatory responses in human mononuclear phagocytes. American Journal of Reproductive Immunology.
http://onlinelibrary.wiley.com/doi/10.1111/aji.12709/full

Keränen, T., Moilanen, E., & Korhonen, R. (2017). Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells. Inflammation Research, 66(5), 441-449.
https://link.springer.com/article/10.1007/s00011-017-1028-4

de Sousa, M. M. L., Bjørås, K. Ø., Hanssen-Bauer, A., Solvang-Garten, K., & Otterlei, M. (2017). p38 MAPK signaling and phosphorylations in the BRCT1 domain regulate XRCC1 recruitment to sites of DNA damage. Scientific Reports, 7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524842/

2016
Yue, J., & López, J. M. (2016). JNK does not regulate meiotic progression in Xenopus oocytes: The strange case of pJNK and pERK. Developmental biology, 416(1), 42-51.
http://www.sciencedirect.com/science/article/pii/S0012160616301373

Ward, E. (2016). An Exploration into Human Pluripotency and Its Role in the Development of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa Patients.
https://conservancy.umn.edu/handle/11299/185572
(* BIRB796 and SB203580 from Axon Medchem)

Borodkina, A. V., Shatrova, A. N., Nikolsky, N. N., & Burova, E. B. (2016). The role of p38 MAP-kinase in stress-induced senescence of human endometrium-derived mesenchymal stem cells. Cell and Tissue Biology, 10(5), 365-371.
http://online.liebertpub.com/doi/abs/10.1089/scd.2017.0026

Ronkina, N., Lafera, J., Kotlyarov, A., & Gaestel, M. (2016). Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38MAPK/MK2 axis. Scientific reports, 6, 31219.
https://www.nature.com/articles/srep31219?WT.feed_name=subjects_physical-sciences

Бородкина, А. В., Шатрова, А. Н., Никольский, Н. Н., & Бурова, Е. Б. (2016). РОЛЬ МАР-КИНАЗЫ р38 В РАЗВИТИИ СТРЕСС-ИНДУЦИРОВАННОГО СТАРЕНИЯ ЭНДОМЕТРИАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА. ЦИТОЛОГИЯ, 58(6).
http://www.tsitologiya.cytspb.rssi.ru/58_6/borodkina.pdf

Svanborg, C., Mok, K. H., Trulsson, M., Mossberg, A. K., Storm, P., & Ho, C. S. (2016). U.S. Patent No. 9,487,561. Washington, DC: U.S. Patent and Trademark Office.
https://www.google.com/patents/US9487561

Olianas, M. C., Dedoni, S., & Onali, P. (2016). Protection from interferon‐β‐induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation. British journal of pharmacology, 173(19), 2910-2928.
http://onlinelibrary.wiley.com/doi/10.1111/bph.13570/full

B.A. Boswell, A. Korol, J.A. West-Mays, and L.S. Musil. Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Mol. Biol. Cell. 2017, 28(7), 907-921.
http://www.molbiolcell.org/content/28/7/907.full
(* BIRB0796, MK2206, and GSK690693 were from Axon Medchem)

Tong, Ann-Jay, et al. "A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation." Cell 165.1 (2016): 165-179.
http://www.sciencedirect.com/science/article/pii/S009286741600060X 

Bhandari, Sabin, et al. "Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion." Biochemical and biophysical research communications (2016).
http://www.sciencedirect.com/science/article/pii/S0006291X16307446
*BIRB796, PD184352, SB203580 were purchased from Axon Medchem
 
van Dijk, Eline Margaretha, et al. "Non-canonical WNT-5B signalling induces inflammatory responses in human lung fibroblasts." American Journal of Physiology-Lung Cellular and Molecular Physiology (2016): ajplung-00226.
http://ajplung.physiology.org/content/early/2016/03/29/ajplung.00226.2015.abstract

AJ Tong et al. A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation.
Cell. 2016 Feb 24. pii: S0092-8674(16)00060-X.

T Keränen et al. Anti-Inflammatory Effects of β 2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1.
PloS one 11, no. 2 (2016): e0148144.

S Khalid  et al. cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Sci. Rep. 2016, 6, 20930.

2015
Flobak, Å., Baudot, A., Remy, E., Thommesen, L., Thieffry, D., Kuiper, M., & Lægreid, A. (2015). Discovery of drug synergies in gastric cancer cells predicted by logical modeling. PLoS computational biology, 11(8), e1004426.
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004426
(* BIRB 0796 and CHIR99021 - CT99021 from Axon Medchem). 

MB Menon et al. The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.
Autophagy 11, no. 8 (2015): 1425-1427.
*Birb796 and SB202190 from Axon Medchem

R Yamaguchi et al. Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps.
Blood Cells, Molecules, and Diseases, 2015, 55(2), pp.127-133.

LP Wang et al. The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells.
Medical Oncology 32, no. 11 (2015): 1-9.

Mechanism of interleukin-13 production by granulocyte-macrophage colony-stimulating factor-dependent macrophages via protease-activated receptor-2.
Yamaguchi, R., Yamamoto, T., Sakamoto, A., Ishimaru, Y., Narahara, S., Sugiuchi, H., Hirose, E. & Yamaguchi, Y.
Blood Cells, Molecules, and Diseases, 2015, 55(1), 21-26. doi:10.1016/j.bcmd.2015.03.006

Osmostress-Induced Apoptosis in Xenopus Oocytes: Role of Stress Protein Kinases, Calpains and Smac/DIABLO.
Messaoud, N. B., Yue, J., Valent, D., Katzarova, I., & López, J. M.
PLoS ONE 2015, 10(4): e0124482. doi:10.1371/journal.pone.0124482

p38 mitogen-activated protein kinase inhibition enhances in vitro erythropoiesis of Fanconi anemia, complementation group A–deficient bone marrow cells. 
Svahn, J., Lanza, T., Rathbun, K., Bagby, G., Ravera, S., Corsolini, F., ... & Cappelli, E. 
Experimental Hematology. 2015, 43(4), 295-299. doi:10.1016/j.exphem.2014.11.010

2014
Al-Alwan, L. (2014). Consequences of the Interaction between IL-17 Cytokines and Airway Smooth Muscle Cells in the Pathogenesis of Airway Remodeling in Asthma (Doctoral dissertation, McGill University Libraries).
http://digitool.library.mcgill.ca/webclient/StreamGate?folder_id=0&dvs=1503056194545~213

Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD.
Chang, Y., Al-Alwan, L., Alshakfa, S., Audusseau, S., Mogas, A. K., Chouiali, F., ... & Eidelman, D. H.
Age, 2014, 63(9), 69-8.

Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK. 
Zhou, Y., Zhao, W., Xie, G., Huang, M., Hu, M., Jiang, X., ... & Zhang, X. K. (2014). 
Carcinogenesis, 2014, 35(12), 2660-2669. doi: 10.1093/carcin/bgu186

Isolated naive pluripotent stem cells and methods of generating same.
Hanna, Y., Novershtern, N., & Rais, Y. 
U.S. Patent No. 20,140,315,301. 23 Oct. 2014.
*many inhibitors (ca. 31) from Axon Medchem have been cited. 

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency.
Theunissen, T. W., Powell, B. E., Wang, H., Mitalipova, M., Faddah, D. A., Reddy, J., ... & Jaenisch, R. 
Cell Stem Cell 2014, 15(4), 471–487. doi:10.1016/j.stem.2014.07.002

Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK
Y Zhou, W Zhao, G Xie, M Huang, M Hu, X Jiang, D Zeng, J Liu, H Chen, CH Wang and XK Zhang.
Carcinogenesis, 2014, in press. doi: 10.1093/carcin/bgu186

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency.
TW Theunissen, BE Powell, H Wang, M Mitalipova, DA Faddah, J Reddy, ZP Fan, D Maetzel, K Ganz, L Shi, T Lungjangwa, S Imsoonthornruksa, Y Stelzer, S Rangarajan, A D’Alessio, J Zhang, Q Gao, MM Dawlaty, RA Young, NS Gray, R Jaenisch.
Cell Stem Cell, 2014, in press. DOI: 10.1016/j.stem.2014.07.002

Interferon-β counter-regulates its own pro-apoptotic action by activating p38 MAPK signalling in human SH-SY5Y neuroblastoma cells.
S Dedoni, MC Olianas, P Onali.
Apoptosis, 2014 - 10.1007/s10495-014-1024-x

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.
BD Cosgrove, PM Gilbert, E Porpiglia, F Mourkioti, SP Lee, SY Corbel, ME Llewellyn, SL Delp & HM Blau.
Nature Medicine 2014, 20, 255-264. | doi:10.1038/nm.3464

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury. 
Ashraf, M. I., Ebner, M., Wallner, C., Haller, M., Khalid, S., Schwelberger, H., ... & Troppmair, J. 
Cell Communication and Signaling, 2014, 12(1), 6.

Derivation of novel human ground state naive pluripotent stem cells.
O Gafni, L Weinberger, AA Mansour, YS Manor, E Chomsky, D Ben-Yosef, Y Kalma, S Viukov, I Maza, A Zviran, Y Rais,  Z Shipony, Z Mukamel, V Krupalnik, M Zerbib, S Geula, I Caspi, D Schneir, T Shwartz, S Gilad, D Amann-Zalcenstein, S Benjamin, I Amit, A Tanay, R Massarwa, N Novershtern & JH Hanna.
Nature 2013, Published online 30 October 2013. doi:10.1038/nature12745
*CHIR99021 (Axon 1386), PD0325901 (Axon 1408), SB202190 (Axon 1364), BIRB796 (Axon 1358), Y-27632 (Axon 1683) used in this study are procured from Axon Medchem.  

Endoplasmic reticulum-associated ubiquitin conjugating enzyme-Ube2j1 is a novel substrate of MAPKAP kinase-2 involved in MK2-mediated TNFalpha production. 
MB Menon, C Tiedje, J Lafera, N Ronkina, T Konen, A Kotlyarov and M Gaestel.
Biochem. J. 2013, in press. doi:10.1042/BJ20130755
(* SB202190, BX912 and BIRB796 from Axon)  

Chronic HIV Infection Enhances the Responsiveness of Antigen Presenting Cells to Commensal Lactobacillus. 
LH Nagy, I Grishina, M Macal, LA Hirao, WK Hu, S, Sankaran-Walters, CA Gaulke, R Pollard, J Brown, M Suni, AJ Baumler, S Ghanekar, ML Marco, S Dandekar.
PLoS ONE 2013, 8(8): e72789. doi:10.1371/journal.pone.0072789

Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normaland Asthmatic Airway Smooth Muscle Cell Migration. 
LA Al-Alwan, Y Chang, A Mogas, AJ Halayko, CJ Baglole, JG Martin, S Rousseau, DH Eidelman and Q Hamid.
J. Immunol. 2013, 191(5), 2731-2741. 

Intrapulmonary administration of a p38 mitogen activated protein kinase inhibitor partially prevents pulmonary inflammation.
AJ Hoogendijk, SS Pinhanços, T van der Poll & CW Wieland. 
Immunobiology, 2013, 218(4), 435-442.

Inducible cAMP early repressor (ICER) is a novel regulator of RIG-I mediated IFN-β production. Cellular signalling.
IB Johnsen, B Bergstroem, KA Stiberg, L Thommesen, & MW Anthonsen.
Cell. Signal. 2013, 25 (9), 1804-1812.

Attenuation of TNF production and experimentally-induced inflammation by phosphodiesterase 4 inhibitor rolipram is mediated by mitogen-activated protein kinase phosphatase-1.
R Korhonen, T Hömmö, T Keränen, M Laavola, M Hämäläinen, K Vuolteenaho, L Lehtimäki, H Kankaanranta, E Moilanen.
Br. J. Pharmacol. 2013, 169 (7), 1525-1536. DOI: 10.1111/bph.12189

Quantitative In vitro Assay to Measure Neutrophil Adhesion to Activated Primary Human Microvascular Endothelial Cells under Static Conditions. 
Wilhelmsen, K., Farrar, K., & Hellman, J. 
J. Visualized Exp. JoVE, 2013, 78, e50677, doi:10.3791/50677.

FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages. 
Garbati, M. R., Hays, L. E., Keeble, W., Yates, J. E., Rathbun, R. K., & Bagby, G. C. (2013). 
Blood, 2013, 122(18), 3197-3205.

A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET
P Storm, TK Klausen, M Trulsson, J Ho CS, M Dosnon, T Westergren, Y Chao, A Rydström, H Yang, SF Pedersen, C Svanborg.
PLoS ONE 2013, 8(3), e58578. doi:10.1371/journal.pone.0058578

p38 MAP kinase enhances EGF-induced apoptosis in A431 carcinoma cells by promoting tyrosine phosphorylation of STAT1.
PY Kozyulina, LS Okorokova, NN Nikolsky, PS Grudinkin.
Biochem. Biophys. Res. Commu. 2013, 430(1), 331–335.

p38α Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin.
K Katholnig, CC Kaltenecker, H Hayakawa, M Rosner, C Lassnig, GJ Zlabinger, M Gaestel, M Müller, M Hengstschläger, WH Hörl, JM Park, MD Säemann, T Weichhart.
J. Immunol. 2013, 190(4), 1519-1527. doi: 10.4049/jimmunol.1202683
(20 publications from previous review)  

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.
R Megherbi, E Kiorpelidou, B Foster, C Rowe, DJ Naisbitt, CE Goldring, BK Park
Toxicol. Applied Pharmacol. 2009, 238 (2), 120-132. 

Nuclear Localization of p38 MAPK in Response to DNA Damage.
CD Wood, TM Thornton, G Sabio, RA Davis, M Rincon.
Int J Biol Sci. 2009; 5(5), 428–437.

RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells, DEPENDENCE ON TRAF2 AND TAK1.
SS Mikkelsen, SB Jensen, S Chiliveru, J Melchjorsen, I Julkunen, M Gaestel, JSC Arthur, RA Flavell, S Ghosh, SR Paludan.
J. Biol. Chem. 2009, 284, 10774-10782.

Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression.
F Carrozzino, P Pugnale, E Féraille, R Montesano.
Am. J. Physiol. Cell Physiol, 2009, 297 (3), C775-C787.  DOI: 10.1152/ajpcell.00084.2009 

Signaling events leading to peroxiredoxin 5 up-regulation in immunostimulated macrophages.
K Abbasa, J Bretona, CR Picota, V Quesniauxb, C Boutona, JC Drapiera.
Free Rad. Biol. Med 2009, 47 (6), 794–802.

The kinase activity of Rip2 determines its stability and consequently Nod1-and Nod2-mediated immune responses.
C Nembrini, J Kisielow, AT Shamshiev, L Tortola, AJ Coyle, M Kopf, BJ Marsland‡,1
J. Biol. Chem. 284, 19183-19188.

Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells.
J Garibal, É Hollville, B Renouf, C Tétaud, J Wiels.
Cell. Signal. 2010, 22 (3), 467-475.  

The p38 SAPK Is Recruited to Chromatin via Its Interaction with Transcription Factors.
I Ferreiro, M Barragan, A Gubern, E Ballestar, M Joaquin, F Posas.
J Biol. Chem. 2010, 285, 31819-31828.  DOI: 10.1074/jbc.M110.155846 

Mitogen-Activated Protein Kinase Phosphatase-1 Negatively Regulates the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in A549 Human Lung Epithelial Cells.
T Turpeinen, R Nieminen, E Moilanen, R Korhonen.
JPET, 2010, 333 (1) 310-318.  DOI: 10.1124/jpet.109.157438 

Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6. 
I Červenka, J Wolf, J Mašek, P Krejci, WR Wilcox, A Kozubík, G Schulte, JS Gutkind, V Bryja.
Mol. Cell. Biol. 2011, 31(1), 179-189.  DOI: 10.1128/MCB.00550-10  

Attenuation of the acute inflammatory response by dual specificity phosphatase 1 by inhibition of p38 MAP kinase.
Riku Korhonena, Tuija Turpeinena, Ville Taimia, Riina Nieminena, Antonis Goulasa, Eeva Moilanena
Mol. Immunol. 2011, 48 (15–16), 2059–2068.

Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase.
T Turpeinen, R Nieminen, V Taimi, T Heittola, O Sareila, AR Clark, E Moilanen, R Korhonen.
Mediators of Inflammation, 2011, Article ID 127587. doi:10.1155/2011/127587

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.
R Noubade, DN Krementsov, R del Rio, T Thornton, V Nagaleekar, N Saligrama, A Spitzack, K Spach, G Sabio, RJ Davis, M Rincon, C Teuscher.
Blood 2011, 118, 12, 3290-3300. doi: 10.1182/blood-2011-02-336552

Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation.
J Sun, LCS Wang, ZG Fridlender, V Kapoor, G Cheng, LM Ching, SM Albelda.
Biochem. Pharmacol. 2011, 82 (9), 1175–1185.

ERK5 Protein Promotes, whereas MEK1 Protein Differentially Regulates, the Toll-like Receptor 2 Protein-dependent Activation of Human Endothelial Cells and Monocytes. 
K Wilhelmsen, KR Mesa, J Lucero, F Xu, J Hellman.
J. Biol. Chem. 2012, 287, 26478-26494.

The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1.
R Korhonen, N Huotari, T Hömmö, T Leppänen, E Moilanen
Mol. Immunol. 2012, 51 (2), 219-226.

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.
P Anur, J Yates, MR Garbati, S Vanderwerf, W Keeble, K Rathbun, LE Hay, JW Tyner, J Svahn, E Cappelli, C Dufour, GC Bagby.
Blood, 2012, 119 (9), 1992-2002.  DOI: 10.1182/blood-2011-06-354647 

The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.
M Joaquin, A Gubern, D González-Nuñez, EJ Ruiz, I Ferreiro, E de Nadal, AR Nebreda, F Posas.
EMBO J, 2012, 31, 2952-2964.   DOI:10.1038/emboj.2012.122 

Th17-associated cytokines promote human airway smooth muscle cell proliferation.
Y Chang, L Al-Alwan, PA Risse, AJ Halayko, JG Martin, CJ Baglole, DH Eidelman, Q Hamid.
FASEB J. 2012, 26(12), 5152-5160.  doi:10.1096/fj.12-208033 

(This is an incomplete list, updated in AUGUST-2017)

 

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