LY 2584702 tosylate

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2464

CAS [1082949-68-5]

MF C21H19F4N7.C7H8O3S
MW 617.62

Purity: 98%
Soluble in DMSO

LY 2584702 tosylate

Description

Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1; IC50 value 4 nM) with significant synergistic activity with Erlotinib (Axon 1128) and Everolimus (Axon 4149). LY2584702 is selective against 83 other kinases as determined by a ubiquitin kinase panel, and 45 cell surface markers as determined by a CEREP mini panel.

A. Hollebecque et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84.

A. Tolcher et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours. Eur J Cancer. 2014 Mar;50(5):867-75.

H Liu et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Reports 2017 Feb. 18(9):2088–2095.

Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1)

Chemical name

4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine tosylate

Parent CAS No.

[1082949-67-4]

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50 mg	€375.00	In Stock

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LY 2584702 tosylate

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LY 2584702 tosylate

Description

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