AT 13148 dihydrochloride

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2166

CAS [1056901-62-2]

MF C17H16ClN3O.2HCl
MW 386.70

  • Purity: 98%
  • Soluble in DMSO

AT 13148 dihydrochloride

Description

An oral, ATP-competitive inhibitor of multi-AGC kinases with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 caused substantial blockade of AKT, p70S6K (S6K1), PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in cancer cells, with IC50 values of 38, 402, 50, 8, 3, 6, 4, 63 nM for AKT1, AKT2, AKT3, p70S6K, PKA, ROCK1, ROCK2, and SGK3 respectively.
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2 mg €85.00 In Stock
5 mg €125.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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