FMK - RSK inhibitor Fmk

Based on 90 reference(s) in Google Scholar 9 10 90

Axon 1848

CAS [821794-92-7]

MF C18H19FN4O2
MW 342.37

  • Purity: 99%
  • Soluble in DMSO

FMK

Description

Potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; FMK binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. FMK induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.
* FMK (IC50 value 15 nM for RSK2 in vitro) is more potent than another CTKD RSK inhibitor SL-0101 (IC50 value 85 nM for RSK2); while BI-D1870 (Axon 1528) binds at NTKD binding site as a reversible RSK inhibitor. 

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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