GSK 690693

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1729

CAS [937174-76-0]

MF C21H27N7O3
MW 425.48

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

GSK 690693

Description

Potent and ATP-competitive Akt kinase inhibitor, with IC50 to be 2, 13 and 9 nM for Akt1, Akt2 and Akt3 respectively

N Rhodes et al. Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Cancer Res. 2008, 68(7), 2366-2374.

DA Heerding et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J. Med. Chem. 2008, 51(18), 5663-5679.

DS Lew et al. AKT inhibitor, GSK690693, induces growth inhibition and apoptosis in acute lymphoblastic leukemia cell lines. Blood. 2009, 113(8), 1723-1729.

ATP-competitive pan-Akt kinase inhibitor

Chemical name

(S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol

Parent CAS No.

[937174-76-0]

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5 mg	€130.00	In Stock
25 mg	€470.00	In Stock

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GSK 690693

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