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DG2
- S6K1 Inhibitor DG2
- Soluble in DMSO
- MF: C16H17BrN6O
- MW: 389.25
Description
DG2 is a potent, selective, ATP-competitive and cell-permeable p70 ribosomal S6 kinase 1 (S6K1) inhibitor with a reported IC50 value of 9.1 nM.
S6K1 functions downstream of mTORC1 to regulate protein translation, cell growth and metabolic signaling. DG2 is useful for distinguishing S6K1-dependent effects from upstream AKT activity, with reported weak activity against AKT.
Key Features
- Potent S6K1 inhibitor
- IC50: 9.1 nM for S6K1
- ATP-competitive and cell-permeable
- Shows weak reported activity against AKT
Applications
- S6K1 kinase pharmacology
- mTORC1 downstream signaling studies
- Protein translation and cell-growth assays
- Kinase selectivity profiling against AKT pathways
More Information
| Parent CAS No. | 871340-88-4 |
|---|---|
| Chemical Name | 3-bromo-4-(4-(2-methoxyphenyl)piperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine |
| SMILES | C1=NC(N2CCN(C3=CC=CC=C3OC)CC2)=C2C(Br)=NNC2=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H17BrN6O/c1-24-12-5-3-2-4-11(12)22-6-8-23(9-7-22)16-13-14(17)20-21-15(13)18-10-19-16/h2-5,10H,6-9H2,1H3,(H,18,19,20,21) |
| InChiKey | CQXAPCMYRSTDGK-UHFFFAOYSA-N |
| CID | 25243801 |
| Short Description | S6K1 inhibitor |
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