Stem Cell LSC inhibitor Set

Based on 14 reference(s) in Google Scholar 10 10 14

Axon 5005

CAS [N.A.]

MF #N/A
MW #N/A

  • Purity: 99%
  • Soluble in DMSO

Stem Cell LSC inhibitor Set

Description

A convenient set of BMP inhibitor LDN 193189 hydrochloride (Axon 1509), TGF-beta inhibitor SB 431542 (Axon 1661) and GSK-3 inhibitor CHIR 99021 (Axon 1386) (termed as LSC or LSB/CHIR by their name abbreviation), for differentiation of human pluripotent stem cells (hPSCs). Combining two-factor neuronal programming with small molecule–based inhibition of GSK-3β by CHIR 99021 (2 µM) and SMAD signaling by LDN 193189 (0.5 µM) and SB 431542 (10 µM), converted postnatal human fibroblasts into functional neuron-like cells with yields up to >200% and neuronal purities up to >80%.

LSC (or LSB/CHIR) inhibitor cocktail protocol can be further extended; with adding SU 5402 (Axon 1667) and DAPT (Axon 1484) to form LSB3i, a 5i inhibitor set (Axon 5007), for rapid differentiating hPSCs into nociceptors.

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Size Unit Price Stock
Each 2 mg €155.00 In Stock
Each 5 mg €205.00 In Stock
Special Offers
Size Unit Price Stock
2 x Each 2 mg €250.00 In Stock
2 x Each 5 mg €345.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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