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JNJ 55511118
- Soluble in DMSO
- MF: C14H8ClF3N2O2
- MW: 328.67
Description
Potent negative modulator of AMPA receptor containing TARP-γ8 (Ki value of 26 nM). JNJ 55511118 exhibits excellent pharmacokinetic properties and achieved high receptor occupancy following oral administration. Tool for reversible AMPA receptor inhibition, particularly within the hippocampus, with potential therapeutic utility as an anticonvulsant or neuroprotectant.
More Information
| Parent CAS No. | 2036081-86-2 |
|---|---|
| Chemical Name | 5-(2-Chloro-6-(trifluoromethoxy)phenyl)-1H-benzo[d]imidazol-2(3H)-one |
| SMILES | C1C(OC(F)(F)F)=C(C2C=CC3NC(=O)NC=3C=2)C(Cl)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21) |
| InChiKey | COBXSLRIXGQVGS-UHFFFAOYSA-N |
| CID | 122656423 |
| Short Description | AMPA negative modulator |
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