Bulk Inquiry
CX516
- BDP-12 - Ampalex
- Soluble in DMSO
- MF: C14H15N3O
- MW: 241.29
Description
CX516 is a centrally and orally active, positive allosteric modulator (PAM) of the AMPA receptor.
More Information
| Parent CAS No. | 154235-83-3 |
|---|---|
| Chemical Name | Piperidin-1-yl(quinoxalin-6-yl)methanone |
| SMILES | C1N=C2C=C(C(N3CCCCC3)=O)C=CC2=NC=1 |
| MFCD | MFCD00943201 |
| InChi | InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2 |
| InChiKey | ANDGGVOPIJEHOF-UHFFFAOYSA-N |
| CID | 148184 |
| Short Description | AMPA PAM |
References
- C Krintel et al. Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. Acta Crystallogr D Biol Crystallogr. 2013;69(Pt 9):1645–1652.
- G Lynch et al. Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Exp Neurol. 1997 May;145(1):89-92.
- A Arai et al. Effects of a memory-enhancing drug on DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents and synaptic transmission in hippocampus. J Pharmacol Exp Ther. 1996 Aug;278(2):627-38.
- J Larson et al. Facilitation of olfactory learning by a modulator of AMPA receptors. J Neurosci. 1995 Dec;15(12):8023-30.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1200 | CNQX |
From $93.50 |
| 1201 | DNQX |
From $55.00 |
| 1217 | CFM 2 |
From $126.50 |
| 1312 | YM 90K hydrochloride |
From $93.50 |
| 1374 | GYKI 53655 |
From $143.00 |
| 1788 | S 18986 |
From $115.50 |
| 2079 | CMPDA |
From $93.50 |
| 2522 | CNQX disodium salt |
From $99.00 |
| 2687 | Farampator |
From $108.90 |
| 2793 | JNJ 55511118 |
From $115.50 |
| 3088 | 1-BCP |
From $82.50 |
| 3090 | CX546 |
From $104.50 |
| 3413 | (RS)-AMPA hydrobromide |
From $143.00 |
| 3415 | AMPA |
From $143.00 |
