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CX546
- Soluble in DMSO
- MF: C14H17NO3
- MW: 247.29
Description
CX546 is a positive allosteric modulator (PAM) of the AMPA receptor. CX546 increased agonist affinity threefold on nondesensitizing AMPA receptors by slowing agonist unbinding.
More Information
| Parent CAS No. | 215923-54-9 |
|---|---|
| Chemical Name | (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone |
| SMILES | C12OCCOC=1C=CC(C(N1CCCCC1)=O)=C2 |
| MFCD | MFCD01860868 |
| InChi | InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2 |
| InChiKey | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
| CID | 2890 |
| Short Description | AMPA PAM |
References
- N Nagarajan et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63.
- JC Lauterborn et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.
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