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Axon 2656
CAS [1438881-19-6]
MF C24H25N5SMW 415.55
Selective ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM, for full-length PKCζ, PKCι, respectively). CRT0066854 decreased colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. A chemical tool to further dissect PKCζ and PKCι roles in establishing cell polarity and growth-factor-stimulated signalling pathways.
KEYWORDS: CRT0066854 | supplier | PKC inhibitor | CRT-0066854 | CAS [1438881-19-6] | Phosphorylation | protein kinase C | aPKC | AGC | PKCζ | PKCι | ATP | LLGL2 | colony | lumen formation | migration | zeta | iota
(2S)-3-phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine
[1438881-19-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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