Based on 15 reference(s) in Google Scholar 10 10 15

Axon 2656

CAS [1438881-19-6]

MF C24H25N5S
MW 415.55

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO



Selective ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM, for full-length PKCζ, PKCι, respectively). CRT0066854 decreased colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. A chemical tool to further dissect PKCζ and PKCι roles in establishing cell polarity and growth-factor-stimulated signalling pathways.

KEYWORDS: CRT0066854 | supplier | PKC inhibitor | CRT-0066854 | CAS [1438881-19-6] |  Phosphorylation | protein kinase C | aPKC | AGC | PKCζ | PKCι | ATP | LLGL2 | colony | lumen formation | migration | zeta | iota

Size Unit Price Stock
5 mg €135.00 In Stock
25 mg €495.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €220.00 In Stock
2 x 25 mg €820.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...