CRT0066854

Based on 15 reference(s) in Google Scholar 10 10 15

Axon 2656

CAS [1438881-19-6]

MF C24H25N5S
MW 415.55

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq) and DMSO
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CRT0066854

Description

Selective ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM, for full-length PKCζ, PKCι, respectively). CRT0066854 decreased colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. A chemical tool to further dissect PKCζ and PKCι roles in establishing cell polarity and growth-factor-stimulated signalling pathways.

KEYWORDS: CRT0066854 | supplier | PKC inhibitor | CRT-0066854 | CAS [1438881-19-6] |  Phosphorylation | protein kinase C | aPKC | AGC | PKCζ | PKCι | ATP | LLGL2 | colony | lumen formation | migration | zeta | iota

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Size Unit Price Stock
5 mg €145.00 In Stock
25 mg €525.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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