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Darovasertib
- NVP-LXS196 - LXS-196
Axon 3851
CAS:
1874276-76-2
Purity:
99%
- Soluble in DMSO
- MF: C22H23F3N8O
- MW: 472.47
Description
Darovasertib is an orally bioavailable, potent and selective protein kinase C inhibitor.
More Information
| Parent CAS No. | 1874276-76-2 |
|---|---|
| Chemical Name | 3-Amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N1C(C2C=NC(N)=C(C(=O)NC3N=CC=CC=3N3CCC(N)(C)CC3)N=2)=C(C(F)(F)F)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34) |
| InChiKey | XXJXHXJWQSCNPX-UHFFFAOYSA-N |
| CID | 118873253 |
| Short Description | PKC inhibitor |
References
- JJ Park et al. Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling. Cancer Gene Ther. 2022 Oct;29(10):1384-1393.
- Y Wang et al. PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice. Signal Transduct Target Ther. 2022 Mar 23;7(1):82.
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