NSC 59984

Based on 15 reference(s) in Google Scholar 9 10 15

Axon 2564

CAS [803647-40-7]

MF C12H15N3O4
MW 265.27

  • Purity: 100%
  • Soluble in 0.1N HCl(aq) and DMSO

NSC 59984

Description

Activator of p53 that restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells, inducing cell death in colorectal cancer cells with minimal genotoxicity and without evident toxicity toward normal cells. Remarkebly, NSC 59984 induces degradation of several p53 mutants through MDM2-mediated ubiquitination.

KEYWORDS: NSC 59984 | supplier | p53 activator | NSC59984 | NSC-59984 | CAS [803647-40-7] | DNA-RNA | p53 | Activator | Transcription Factor | MDM2 | p73 | HDM | colorectal | cancer | ubiquitination | apoptosis

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Size Unit Price Stock
10 mg €95.00 In Stock
50 mg €335.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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