Bulk Inquiry
IM 12
- Soluble in DMSO
- MF: C22H20FN3O2
- MW: 377.41
Description
IM 12 is a GSK-3β inhibitor with an IC50 value of 53 nM, showing a bell-shaped dose-response relationship. IM12 enhances canonical Wnt signalling, and attenuates cell proliferation and neuronal differentiation of human neural progenitor cells with similar potency as SB 216763 (Axon 1303).
*Promotion: IM 12 is an important component of Inhibitor Set(s):
| Naive Stem Cell 5i inhibitor Set (Axon 5011) |
More Information
| Parent CAS No. | 1129669-05-1 |
|---|---|
| Chemical Name | 3-(4-fluorophenethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
| SMILES | N1(C)C(=O)C(C2C3=C(NC=2C)C=CC=C3)=C(NCCC2=CC=C(F)C=C2)C1=O |
| MFCD | MFCD20527313 |
| InChi | InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3 |
| InChiKey | ZKJAZFUFPPSFCO-UHFFFAOYSA-N |
| CID | 25209788 |
| Short Description | GSK-3β inhibitor |
References
- A.C. Schmöle et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.
- A. Brennführer et al. Catalytic and Stoichiometric Synthesis of Novel 3-Aminocarbonyl-, 3-Alkoxycarbonyl-, and 3-Amino-4-indolylmaleimides. Eur. J. Org. Chem., 2009: 38-42.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1126 | CHIR98014 |
From $108.90 |
| 1303 | SB 216763 |
From $93.50 |
| 1386 | CHIR99021 |
From $66.00 |
| 1527 | XAV939 |
From $88.00 |
| 1562 | TWS 119 |
From $77.00 |
| 1693 | BIO |
From $99.00 |
| 1766 | ICG 001 |
From $126.50 |
| 1909 | A 1070722 |
From $104.50 |
| 1922 | JW 55 |
From $104.50 |
| 2010 | TDZD 8 |
From $99.00 |
| 2036 | KY 02111 |
From $88.00 |
| 2084 | SKL 2001 |
From $99.00 |
| 2120 | Wnt agonist 1 |
From $99.00 |
| 2133 | iCRT5 |
From $99.00 |
| 2167 | AR-A 014418 |
From $93.50 |
| 2171 | AZD1080 |
From $99.00 |
| 2188 | WAY 262611 dihydrochloride |
From $137.50 |
| 2194 | AZD2858 hydrochloride |
From $104.50 |
| 2212 | IWP L6 |
From $143.00 |
| 2287 | Wnt-C59 |
From $82.50 |
| 2435 | CHIR99021 dihydrochloride |
From $66.00 |
| 2901 | KHS101 hydrochloride |
From $104.50 |
| 2931 | BRD0705 |
From $231.00 |
| 3153 | BRD5648 |
From $198.00 |
