GSK 2110183 hydrochloride - Afuresertib hydrochloride

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2460

CAS [1047645-82-8]

MW 463.78

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in water and DMSO

GSK 2110183 hydrochloride


Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases (Ki values 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively), with some inhibitory effect on PKA and PKG1a. GSK2110183 preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation, and various cell lines derived from hematologic malignancies, in an ATP-competitive manner and with a minimal effect on glucose homeostasis.
Size Unit Price Stock
5 mg €105.00 In Stock
25 mg €365.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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