GSK 2110183 hydrochloride - Afuresertib hydrochloride

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2460

CAS [1047645-82-8]

MF C18H17Cl2FN4OS.HCl
MW 463.78

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

GSK 2110183 hydrochloride

Description

Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases (Ki values 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively), with some inhibitory effect on PKA and PKG1a. GSK2110183 preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation, and various cell lines derived from hematologic malignancies, in an ATP-competitive manner and with a minimal effect on glucose homeostasis.

M. Dumble et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880.

A. Spencer et al. The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 2014 Oct 2;124(14):2190-5.

Potent, reversible, selective, and orally bioavailable inhibitor of the Akt kinases

Chemical name

N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Parent CAS No.

[1047644-62-1]

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GSK 2110183 hydrochloride - Afuresertib hydrochloride

Description

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Parent CAS No.

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GSK 2110183 hydrochloride - Afuresertib hydrochloride

Description

Chemical name

Parent CAS No.

Related Products

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