NG 25 trihydrochloride

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2366

CAS [N.A.]

MF C29H30F3N5O2.3HCl
MW 646.96

  • Purity: 98%
  • Soluble in water and DMSO

NG 25 trihydrochloride

Description

Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) with nanomolar potency for a wider range of kinases (IC50 values 13 nM, 22 nM, 56 nM, 75 nM, 82 nM, 102 nM, 113 nM, and 149 nM for LYN, MAP4K2, CSK, Abl, FER, p38α, SRC, and TAK1, repectively). At 0.1 µM NG25 shows strong inhibition of TAK1, Lck, MAP4K2, p38α, Abl, YES1, and OSR1. NG 25 potently inhibited the activation of IKKβ by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
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Size Unit Price Stock
2 mg €85.00 In Stock
10 mg €185.00 In Stock
50 mg €725.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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