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ML 351
- Soluble in DMSO
- MF: C15H11N3O
- MW: 249.27
Description
ML 351 is a potent and selective 12/15-lipoxygenase inhibitor with an IC50 value of 200 nM against human 12/15-LOX and greater than 250-fold selectivity over related lipoxygenase isozymes. It protects neuronal HT22 cells from oxidative glutamate toxicity and reduces infarct size in mouse ischemic stroke models.
12/15-LOX contributes to lipid oxidation, oxidative cell death and ischemic neuronal injury. ML 351 is useful for studying lipoxygenase-dependent neurotoxicity and lipid-peroxidation mechanisms in stroke and inflammatory disease research.
Key Features
- Selective 12/15-LOX inhibitor
- IC50: 200 nM against human 12/15-LOX
- Greater than 250-fold selectivity over related LOX enzymes
- Neuroprotective in oxidative glutamate toxicity and stroke models
Applications
- Lipoxygenase pharmacology
- Ischemic stroke research
- Oxidative neuronal injury assays
- Lipid oxidation pathway studies
More Information
| Parent CAS No. | 847163-28-4 |
|---|---|
| Chemical Name | 5-(methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile |
| SMILES | O1C(NC)=C(C#N)N=C1C1=C2C(C=CC=C2)=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3 |
| InChiKey | DYXYXTDIFMDJIR-UHFFFAOYSA-N |
| CID | 664510 |
| Short Description | Lipoxygenase inhibitor |
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