PRMT3 inhibitor 1 - Compound 1

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2211

CAS [1340875-03-7]

MF C15H18N4OS
MW 302.39

  • Purity: 99%
  • Soluble in DMSO

PRMT3 inhibitor 1

Description

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3; IC50 value of 1.6 μM for inhibition of full length PRMT3 in a radioactivity-based assay). PRMT3 inhibitor 1 showed no inhibitory activity on any of the PKMTs G9a, EHMT1, SUV39H2, SETD7, and SETD8, and PRMTs PRMT1, PRMT4, PRMT5, and PRMT8.The allosteric binding site of compound 1 was localized by site-directed mutagenesis of PRMT3 and X-ray crystallography.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

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