WAY 262611 dihydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2188

CAS [N.A.]

MF C20H22N4.2HCl
MW 391.34

  • Purity: 99%
  • Soluble in water and DMSO

WAY 262611 dihydrochloride

Description

Inhibitor of Dickkopf-1 (DKK1); WAY 262611 is a wingless Wnt/β-Catenin signaling agonist with an inhibitory effect on DKK1, displaying an EC50 value of 0.63 μM for DKK1-mediated TCF-Luciferase, no affinity for GSK-3β (IC50 value >100 μM) and enhancing the bone formation rate in ovariectomized (OVX) rats following oral adminstration. Dickkopf-1 (DKK1) is a soluble inhibitor of Wnt-3a mediated Wnt/β-catenin signaling required for embryonic head development. It regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein-related protein-5 (LRP5)/Arrow, and Kremen2 (Kr2) simultaneously.
Order
Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €425.00 In Stock
Special Offers
Size Unit Price Stock
2 x 10 mg €180.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...