Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis (embryonic induction, generation of cell polarity, and the specification of cell fate). Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP (low density Lipoprotein Receptor-related Protein) families on the cell surface. The result is alleviation of pathway inhibition caused by GSK-3β, APC, and Axin proteins. This stabilizes β-Catenin and promotes its nuclear translocation where it regulates target gene transcription together with Tcf/Lef proteins. During development, the Wnt/β-catenin pathway integrates signals from many other pathways including Retinoic acid, FGF, TGF-β, and BMP in many different cell-types and tissues. In addition, GSK-3β is also involved in glycogen metabolism and other key pathways, which has made its inhibition relevant to diabetes and neurodegenerative disorders[1],[2].

[1] Wnt signaling and stem cell control. Nusse, R. Cell Research 2008,18, 523-527.
[2] Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors. M. D. Gordon, R. Nusse. J Biol Chem. 2006, 281, 22429-22433.

13 Item(s)

per page
Axon ID Name Description From price
2161 CCT 031374 hydrobromide Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway €60.00
1766 ICG 001 Specific inhibitor of Wnt/β-catenin signaling pathway €115.00
2135 iCRT14 Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor €135.00
2133 iCRT5 β-Catenin-responsive transcription (CRT) inhibitor €80.00
3948 ISX9 Wnt/β-catenin signaling pathway agonist €110.00
2036 KY 02111 Canonical Wnt signaling pathway inhibitor €80.00
2668 KYA1797K Promotor of β-catenin and Ras degradation that effectively suppresses the growth of CRCs €95.00
3342 MSAB Potent and selective inhibitor of Wnt/β-catenin signaling pathway €80.00
2084 SKL 2001 Wnt/β-catenin signaling pathway agonist or activator €90.00
2188 WAY 262611 dihydrochloride Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist €125.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
3206 YW2065 Inhibitor of Wnt/β-catenin signalling; AMPK activator €95.00

13 Item(s)

per page
Please wait...