UK 383367

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2073

CAS [348622-88-8]

MF C15H24N4O4
MW 324.38

Purity: 99%
Soluble in DMSO

UK 383367

Description

Potent and selective inhibitor of bone morphogenetic protein 1 (BMP-1; also known as procollagen C proteinase, PCP) with IC50 values of 44 nM for BMP-1 and >10.000 nM for a range of other proteolytic matrix metalloproteinases MMP-1, 2, 3, 9, and 14.

PV Fish et al. Potent and Selective Nonpeptidic Inhibitors of Procollagen C-Proteinase. J. Med. Chem. 2007, 50, 3442-3456.

GA Allan et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006, 36, 399-418.

S Bailey et al. Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg. Med. Chem. Lett. 2008, 18, 6562-6567.

Inhibitor of bone morphogenetic protein 1 (BMP-1, aka PCP)

Chemical name

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide

Parent CAS No.

[348622-88-8]

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5 mg	€90.00	In Stock
25 mg	€320.00	In Stock

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UK 383367

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