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Rolofylline metabolite M1-cis
- Compound 4
- Soluble in DMSO and EtOH
- MF: C20H28N4O3
- MW: 372.46
Description
Rolofylline metabolite M1-cis is an active cis metabolite of rolofylline and functions as an adenosine A1 receptor antagonist.
Adenosine A1 receptor activity influences renal vascular tone, sodium handling, cardiac conduction and neurotransmission. Rolofylline metabolite M1-cis supports comparative analysis of rolofylline metabolites and A1 receptor antagonist pharmacology.
Key Features
- Active rolofylline metabolite
- Adenosine A1 receptor antagonist
- Cis isomer for metabolite activity comparison
- Useful for adenosine receptor pharmacology studies
Applications
- Adenosine A1 receptor assays
- Rolofylline metabolite comparison studies
- Renal and cardiovascular pharmacology research
- GPCR antagonist profiling
More Information
| Parent CAS No. | 161167-65-3 |
|---|---|
| Chemical Name | 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, cis |
| SMILES | C12CC3C(C4=NC5N(CCC)C(=O)N(CCC)C(=O)C=5N4)(C1)CC(C3)C2O |
| MFCD | N.A. |
| InChi | InChI=1S/C20H28N4O3/c1-3-5-23-16-14(17(26)24(6-4-2)19(23)27)21-18(22-16)20-9-11-7-13(20)8-12(10-20)15(11)25/h11-13,15,25H,3-10H2,1-2H3,(H,21,22) |
| InChiKey | RQXXBTUEEJCGNQ-UHFFFAOYSA-N |
| CID | 9885824 |
| Short Description | A1 antagonist |
References
- W Radziszewski et al. A single supratherapeutic dose of rolofylline does not prolong the QTcF interval in healthy volunteers. Am. J. Ther. 2010, 17(1), 8-16.
- M Stroh et al. The Effects of Multiple Doses of Rolofylline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Subjects. Am. J. Ther. 2010, 17(1), 53-60.
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