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Rolofylline metabolite M1-trans
- Compound 3
- Soluble in DMSO
- MF: C20H28N4O3
- MW: 372.46
Description
Rolofylline metabolite M1-trans is an active trans metabolite of rolofylline and functions as an adenosine A1 receptor antagonist.
Adenosine A1 receptors regulate renal hemodynamics, tubular function, cardiac conduction and CNS neurotransmission. Rolofylline metabolite M1-trans is useful for comparing metabolite activity with parent A1 antagonists in cardiorenal pharmacology studies.
Key Features
- Active rolofylline metabolite
- Adenosine A1 receptor antagonist
- Trans isomer for metabolite pharmacology comparison
- Relevant to cardiorenal adenosine signaling research
Applications
- Adenosine A1 receptor pharmacology
- Rolofylline metabolite profiling
- Renal and cardiorenal signaling studies
- GPCR antagonist comparison assays
More Information
| Parent CAS No. | 160943-06-6 |
|---|---|
| Chemical Name | 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine-2,6-dione, trans |
| SMILES | C12CC3C(C4=NC5N(CCC)C(=O)N(CCC)C(=O)C=5N4)(C1)CC(C3)C2O |
| MFCD | N.A. |
| InChi | InChI=1S/C20H28N4O3/c1-3-5-23-16-14(17(26)24(6-4-2)19(23)27)21-18(22-16)20-9-11-7-13(20)8-12(10-20)15(11)25/h11-13,15,25H,3-10H2,1-2H3,(H,21,22) |
| InChiKey | RQXXBTUEEJCGNQ-UHFFFAOYSA-N |
| CID | 9885824 |
| Short Description | A1 antagonist |
References
- W Radziszewski et al. A single supratherapeutic dose of rolofylline does not prolong the QTcF interval in healthy volunteers. Am. J. Ther. 2010, 17(1), 8-16.
- M Stroh et al. The Effects of Multiple Doses of Rolofylline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Subjects. Am. J. Ther. 2010, 17(1), 53-60.
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